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A generalized urticarial reaction, which required systemic corticosteroid therapy and possibly was causally related to erythromycin, has been reported during topical use of the gel.	Continued elution gave fractions containing a mixture of 11-o-methylsulfinylmethyl-6,6a-anhydroerythromycin b (iii) and 11-o-methylsulfinylmethyl-6,7-anhydroerythromycin b (iv).